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The toxin first docks to the active zone blue by binding to two membrane-anchored receptors, synaptotagmin red and ganglioside yellow. In addition, health claims made on the label and in commercials must be substantiated, which is the main problem for so-called cosmeceuticals—products that are claimed to have drug-like benefits. The treatment of damaged or ageing skin is an important area in which the interests of medicine and cosmetics collimate most obviously, and one where the line between cosmetics and medicine is most evanescent Giacomoni, The question is whether this is enough evidence to ban the cosmetic use of BoNTs. Episkin is not only a good research tool, but was also validated by the European Centre for the Validation of Alternative Methods Ispra, Italy as a potential replacement for current methods to assess the skin-irritancy potential of cosmetic ingredients and products, without using animals. Even today, many women and men devote considerable amounts of time and money to selecting and applying the right combination of cosmetic products, and thus drive a huge—and still growing—cosmetics industry.

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